RRs (95% CI) from full, ischemic, and you may hemorrhagic shots by the quintiles from shared diet scores to own magnesium, potassium, and you may calcium supplements intakes when you look at the 86,149 feamales in the newest NHS I and 94,715 ladies in the newest NHS II 1

I current this new meta-analyses from prospective degree regarding weight loss magnesium ( 21), potassium ( 22), and you will calcium ( 23) intakes and you can danger of coronary attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) out-of complete, ischemic, and you may hemorrhagic shots by the quintiles of joint eating plan results to possess magnesium, potassium, and you will calcium intakes during the 86,149 ladies in the fresh NHS We and you will 94,715 feamales in the brand new NHS II 1

I upgraded the fresh meta-analyses from possible knowledge out-of diet magnesium ( 21), potassium ( 22), and you will calcium ( 23) consumption and danger of heart attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake https://datingranking.net/japanese-dating/ and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

I examined complete and you will diet consumption of any nutrient and you will exposure of heart attack to decide any possible nonlinear relationship that with limited cubic splines; but not, no tall deviation out-of linearity is seen. While doing so, we searched the possibility feeling amendment by many years, blood pressure, or diabetic issues on family relations ranging from total consumption of all the step 3 minerals and you will chance of full stroke. Zero extreme impression amendment try observed by such points.

Previous meta-analyses incorporated comes from earlier in the day analyses from the NHS ( 10); these types of overall performance had been replaced by the leads to the current research. Simultaneously, the fresh literature is searched, and you may latest potential degree ( 8, 24) was indeed included in these types of current meta-analyses. No anywhere between-education heterogeneity is actually seen for any of one’s 3 vitamins. The latest mutual RR out of overall stroke are 0.87 (95% CI: 0.83, 0.92) to own an one hundred-mg/d improve of magnesium intake, 0.91 (95% CI: 0.88, 0.94) to own good 1000-mg/d raise away from potassium intake, and you can 0.98 (95% CI: 0.94, step one.02) to have a 300-mg/d increase out of calcium consumption.